Advances in Hippo signaling pathway in oral squamous cell carcinoma
10.3760/cma.j.cn112144-20200611-00333
- VernacularTitle:Hippo信号通路在口腔鳞状细胞癌中的研究进展
- Author:
Wanqiu XU
1
;
Xiaohang XU
;
Chang LIU
;
Lihong YAO
;
Xiumei WANG
Author Information
1. 哈尔滨医科大学附属第二医院牙体牙髓科 150000
- Keywords:
Oral sprays;
Hippo signaling pathway;
Molecular targeted therapy;
Drug resistance;
Drug combination
- From:
Chinese Journal of Stomatology
2021;56(2):221-225
- CountryChina
- Language:Chinese
-
Abstract:
Oral squamous cell carcinoma (OSCC) is a common cancer that develops from oral epithelial cells, it has a high incidence, mortality and teratogenic rate, which poses a serious threat to people′s life and health.The Hippo signaling pathway plays a key role in tumorigenesis, regulation of stem cell homeostasis, tissue regeneration, and organ size control. In OSCC, activation of Hippo signaling pathway can inhibit malignant biological behavior, epithelial mesenchymal transformation and distant metastasis of tumors, and improve the survival rate of patients. Considering the importance of the Hippo signaling pathway in the development of cancer, this paper summarized the composition and regulatory mechanism of Hippo pathway, elaborated the role of Hippo signaling pathway in the occurrence and development of OSCC.At the same time, make a simple generalization about the potential therapeutic approaches and strategies to reduce the risk of drug resistance for OSCC patients targeting this pathway.
