S100A8/A9 and periodontal inflammatory diseases
10.3760/cma.j.cn112144-20191210-00445
- VernacularTitle:S100A8/A9蛋白与牙周炎症性疾病关系的研究进展
- Author:
Hongyu GAO
1
;
Huanxin MENG
;
Jianxia HOU
Author Information
1. 北京大学口腔医学院·口腔医院牙周科 国家口腔疾病临床医学研究中心 口腔数字化医疗技术和材料国家工程实验室 口腔数字医学北京市重点实验室 100081郜洪宇现在天津医科大学口腔医院牙周科 300070
- Keywords:
Calcium-binding proteins;
Calgranulin A;
Calgranulin B;
Periodontitis;
Gingivitis
- From:
Chinese Journal of Stomatology
2020;55(9):679-684
- CountryChina
- Language:Chinese
-
Abstract:
Calprotectin S100A8/A9, a heterodimer composed of S100A8 and S100A9, is the main component of cytoplasmic proteins in neutrophils. It plays multiple roles in the immuno-inflammatory reactions intracellularly and extracellularly. Recent studies find that S100A8/A9 is closely related with the initiation and progression of periodontal inflammatory diseases. S100A8/A9 is expected to be a new biomarker for diagnosing periodontal inflammatory diseases, monitoring inflammatory activities in patients with periodontitis, evaluating the outcome of periodontal treatments and predicting the susceptibility of individual patient to periodontitis. In this literature review, we summarize the clinical research progress on the relation between S100A8/A9 and periodontal inflammatory diseases.
