Mechanisms and regulations in tooth root development

VernacularTitle:牙根发育调控机制的研究进展
Author: Yuning ZHANG ¹ ; Jun WANG ; Chenchen ZHOU
Author Information

1. 四川大学华西口腔医院儿童口腔科　口腔疾病研究国家重点实验室　国家口腔疾病临床医学研究中心，成都　610041
Keywords: Tooth root; Dentin; Tooth root development; Epithelial root sheath; Signaling pathway
From: Chinese Journal of Stomatology 2020;55(8):591-594
CountryChina
Language:Chinese
Abstract: Tooth loss caused by trauma, periodontitis or inherited disorders severely affects human physical and mental health. As an essential part of the tooth, tooth root is connected to periodontal tissues to maintain the tooth in the alveolar socket. To figure out the molecular mechanisms regulating tooth root development will contribute to the discovery of new approaches in tooth root regeneration. The development of tooth root is a complicated process involving communication between the epithelial and mesenchymal tissues and the regulation of multiple signaling pathways. The present article reviewed the research progress of the signaling pathways in tooth root development.