Research progress in the treatment and prevention of medication-related osteonecrosis of the jaw
10.3760/cma.j.cn112144-20191021-00376
- VernacularTitle:药物相关性颌骨坏死治疗及预防的研究进展
- Author:
Luchen XU
1
;
Yunfeng LI
Author Information
1. 四川大学华西口腔医院正颌及关节外科 口腔疾病研究国家重点实验室 国家口腔疾病临床医学研究中心，成都 610041
- Keywords:
Osteonecrosis;
Jaw;
Medication-related osteonecrosis of the jaw;
Treatment;
Prevention
- From:
Chinese Journal of Stomatology
2020;55(7):509-514
- CountryChina
- Language:Chinese
-
Abstract:
Medication-related osteonecrosis of the jaw (MRONJ) is a severe complication of anti-resorption drugs and anti-angiogenesis drugs. Its mechanism is still unclear, which may be related to bone remodeling inhibition, angiogenesis inhibition, inflammation, etc. The main clinical symptoms are continuous infection, recurrent swelling and pain and impacting the patients′ quality of life. Because of its serious symptoms and unclear treatment, MRONJ has attracted wide attention. Now there are many researches on the treatment and prevention of MRONJ. The treatment includes conservative treatment and surgical treatment. There is no clear evidence of the effectiveness of existing methods of prevention and treatment of MRONJ, and lacking the unified and accepted standard methods of prevention and treatment. In this article, current researches of the prevention and treatment of MRONJ are reviewed, including the mechanism of the methods.
