Two Cases of Infection-associated Hemophagocytic Syndrome with Review of Literature.
- Author:
Dong Ryeol RYU
1
;
Joon Sup YEOM
;
Kyung Hee CHANG
;
Sung Kwan HONG
;
Yoon Soo PARK
;
Young Hwa CHOI
;
Young Goo SONG
;
Woo Ick YANG
;
Nae Choon YOO
;
Jee Sook HAHN
;
June Myung KIM
Author Information
1. Department of Internal Medicine, College of Medicine, Yonsei University, Seoul, Korea.
- Publication Type:Case Report
- Keywords:
Hemophagocytic syndrome;
Infection- associated hemophagocytic syndrome;
Outcome
- MeSH:
Bacterial Infections;
Blood Cells;
Diagnosis;
Female;
Histiocytes;
Humans;
Lymphohistiocytosis, Hemophagocytic*;
Male;
Mortality;
Phagocytosis
- From:Korean Journal of Infectious Diseases
1998;30(5):470-477
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The hemophagocytic syndrome is a disorder caused by systemic proliferation of benign histiocytes with avid phagocytosis of blood cells. Although this is an established disease entity, early clinical diagnosis is often difficult. The disease is known to be rare. The clinical and laboratory characteristics of 33 patients with the infection-associated hemophagocytic syndrome were reviewed which included previously reported 31 cases from the literature, and 2 recent cases presented in this study. The patients were 22 males and 11 females with a mean age of 20.8 years(range 1 to 69 years). Ten patients were associated with viral infection and seven with bacterial infection. The infection usually occurs in patients with preexisting immunological abnormalities, but in this study underlying illness was found in only 8 out of the 33 cases. The overall mortality rate was 63.6%, which is a higher percentage than in other countries. Since the clinical course can be fulminant, accurate diagnosis and effective treatment are needed.
