Applications of stem cell-derived extracellular vesicles in bone regenerative therapy
10.3760/cma.j.issn.1002-0098.2020.03.013
- VernacularTitle:干细胞细胞外囊泡在骨再生治疗中的应用
- Author:
Yuzi SHAO
1
;
Si CHEN
;
Yongsheng ZHOU
Author Information
1. 北京大学口腔医学院·口腔医院修复科 国家口腔疾病临床医学研究中心 口腔数字化医疗技术和材料国家工程实验室 口腔数字医学北京市重点实验室 100081
- Keywords:
Stem cells;
Exosomes;
Bone regeneration;
Extracellular vesicles
- From:
Chinese Journal of Stomatology
2020;55(3):206-211
- CountryChina
- Language:Chinese
-
Abstract:
Stem cell-derived exosomes and microvesicles are nanoscale extracellular vesicles which have merged as mediators of intercellular communication through delivering bioactive substances. They have showed promising potential in regenerative therapy due to their capacity in promoting tissue regeneration. It has been reported that stem cell-derived extracellular vesicles could enhance bone regeneration. The underlying mechanisms included inhibiting osteocyte apoptosis induced by ischemia and hypoxia, enhancing the proliferation, migration, and osteogenic differentiation of stem cells, and promoting angiogenesis. Further investigations indicated that microRNA seemed to play an important role in exosome-mediated regeneration. In this review, we summarized the biogenesis, components and functions of stem cell-derived extracellular vesicles as well as the current progress of their mechanisms and applications in bone regeneration.
