The concept of field cancerization and its clinical application

VernacularTitle:区域癌化的概念及其临床应用
Author: Zihao WEI ¹ ; Wang GONG ; Min ZHOU ; Qianming CHEN
Author Information

1. 四川大学华西口腔医学院黏膜科
Keywords: Carcinoma,squmous cells; Field cancerization; Head and neck neoplasms; Neoplasms,multiple primary; Neoplasms,second primary
From: Chinese Journal of Stomatology 2016;51(9):562-565
CountryChina
Language:Chinese
Abstract: Head and neck squamous cell carcinoma(HNSCC) is among the most common malignances worldwide.Patients with HNSCC often develop primary tumors at multiple sites and have tendency for local recurrences following curative resectional surgery.Field cancerization theory presumes that,after repeated carcinogenic exposures,the entire superficialepitheliium of the upper aerodigestive tract has an increased risk for developing (pre)malignant lesions because of multiple genetic abnormalities.This theorywell explains the strong potential with malignant transformation and loco-regional recurrence in HNSCC,and helps to better understand the pathogenesis,and thus provides a new idea for prevention and treatment of this disease.This paper will give an overview of field cancerization,including the concept and its clinical application.