Oxidative stress and antioxitant therapy of chronic periodontitis
10.3760/cma.j.issn.1002-0098.2016.07.013
- VernacularTitle:慢性牙周炎的氧化应激及抗氧化治疗研究进展
- Author:
Yanxin SHEN
1
;
Shujuan GUO
;
Yafei WU
Author Information
1. 四川大学口腔疾病研究国家重点实验室
- Keywords:
Chronic periodontitis;
Oxidative stress;
Antioxidants;
Reactive oxygen species
- From:
Chinese Journal of Stomatology
2016;51(7):442-446
- CountryChina
- Language:Chinese
-
Abstract:
Chronic periodontitis is a progressive,infectious inflammation disease,caused by the dysbiosis of oral resident flora,leading to the destruction of periodontium.The onset of pathogenic microorganisms is the etiological factor of periodontitis,while the immuno-inflammatory response affects the progression of the disease.Under chronic periodontitis,oxidative stress occurs when excessive reactive oxygen species are produced and exceed the compensative capacity of the organism.Oxidative stress leads to the destruction of periodontium,in a direct way(damaging the biomolecule) or an indirect way(enhancing the produce of inflammatory cytokine and destructive enzymes).Therefore,as the antagonist of the reactive oxygen species,antioxidants may be helpful to treat the chronic periodontitis.This paper reviewed relevant literatures about the destructive role of excessive reactive oxygen species and protective role of antioxidants in chronic periodontitis.
