Clinical and radiologic characteristics of craniomaxillofacial primary tumor induced osteomalacia:a retrospective analysis
10.3760/cma.j.issn.1002-0098.2016.06.005
- VernacularTitle:诱发低磷骨软化症的颅颌面原发肿瘤临床与影像学特点回顾分析
- Author:
Mu WANG
1
;
Lian ZHOU
;
Huadan XUE
;
Yan JIANG
;
Dingrong ZHONG
;
Zhaohui ZHU
Author Information
1. 中国医学科学院北京协和医学院北京协和医院口腔科
- Keywords:
Osteomalacia;
Positron-emission tomography;
Octreotide;
Tumor induced osteomalacia;
Phosphaturicmesenchymal tumor
- From:
Chinese Journal of Stomatology
2016;51(6):341-345
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the diagnosis strategy,radiology and clinical pathology feature of craniomaxillofacial primary tumor induced osteomalacia.Methods Twelve cases of craniomaxillofacial primary tumor induced osteomalacia were reviewed,including 5 male and 7 female with a age range from 16 to 69 years.The clinical characteristics,radiology examinations and pathological features were analyzed.Results The craniomaxillofacial primary tumor induced osteomalacia occurred in different ages,with 2 to 30 years of medical history.Seven of the twelve cases were octreotide scintigraphy positive,nine of the twelve cases invaded bone,exhibiting destruction of the adjacent cortex,ten of the twelve showed gingival lesions of local thickening or epulis.The tumor arises from mesenchymal tissue,infiltrating local gingiva and bone trabeeular with spindle like fibroblasts and dental epithelial rests.Conclusions The concealed nature of the tumor induced osteomalacia requires multiple methods to locate the primary tumor and the tumors located in craniomaxillofacial region have unique clinical and pathological features.
