Expression of DJ-1、 phophatase and tensin homolog deleted on chromosome 10 and focal adhesion kinase in oral squamous cell carcinoma and precancerous lesions
10.3760/cma.j.issn.1002-0098.2012.s1.052
- VernacularTitle:DJ-1、张力蛋白同源10q丢失的磷酸酶基因和黏着斑激酶在口腔癌及癌前病变中的表达
- Author:
Cao YIN
1
;
Si-Ming XIE
;
Xi CHEN
;
Ting-Ting ZHU
;
Fu-Fang ZHANG
;
Li-Jia SHEN
Author Information
1. 广东省口腔医院·南方医科大学附属口腔医院黏膜牙周科
- Keywords:
Oral sprays;
Oral precancerous lesion;
Focal adhesion kinase;
DJ-1
- From:
Chinese Journal of Stomatology
2012;47(z1):227-232
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of DJ-1,phophatase and tensin homolog deleted on chromosome 10 (PTEN) and focal adhesion(FAK) in patients with oral squamous cell carcinoma (OSCC) and precancerous lesions.Methods Immunohistochemical staining (SP method) was used to detect the expression of DJ-1 and PTEN in the biopsy mucosa tissues from 44 cases of oral squamous cell carcinoma,20 cases of hyperplasia of oral mucosa,15 cases of dysplasia of oral mucosa and 10 cases of normal mucosa.Results The positive rate of DJ-1 in OSCC was 91％ (40/44),which was significandy higher than that in other non-malignant groups including hyperplasia(50％),dysplasia (67％)and normal mucosa(30％) (P ＜ 0.05).The positive rates of PTEN was 45％ (20/44) in OSCC,which were significantly lower than that in other non-malignant groups (P ＜ 0.05) including hyperplasia (100％),dysplasia (87％)and normal mucosa(100％) (P ＜0.05).The positive rates of FAK was 80％ (35/44) in OSCC,which were significantly lower than that in other non-malignant groups (P ＜ 0.05) including hyperplasia(100％),dysplasia(95％) and normal mucosa(100％) (P ＜ 0.05).In all of these tissues,a negative correlation was found between the expression of DJ-1 and PTEN (r =-0.75,P ＜ 0.05),while a positive correlation was found between the expression of DJ-1 and PTEN (r =0.28,P ＜ 0.05).Conclusions DJ-1,PTEN and FAK may play an important role in the pathogenesis of OSCC.
