Clinical outcomes of all-trans retinoic acid compound and capsule of total glucosides of paeony for the treatment of reticular oral lichen planus:a half-year follow-up study
10.3760/cma.j.issn.1002-0098.2012.s1.027
- VernacularTitle:复方维甲酸软膏联合白芍总苷胶囊治疗斑纹型口腔扁平苔藓半年疗效观察
- Author:
Yan DU
1
;
Jin-Fan PANG
;
Long OU
;
Rong-Sen LIU
;
Xian-Hua ZHANG
;
Hong-Chen LIU
Author Information
1. 解放军总医院牙周黏膜病科
- Keywords:
Tretinoin;
Treatment outcome;
Oral lichen planus;
Recurrence;
Total glucosides of paeony
- From:
Chinese Journal of Stomatology
2012;47(z1):118-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate of the clinical effects of the combined use of all-trans retinoic acid compound and capsule of total glucosideof paeony on reticular oral lichen planus.Methods A total of 120 patients were randomly divided into 3 groups:experimental group (group E),control group 1 (group C1),and control group 2 (group C2).Topical application of alltrans-tretioin compound and systematic administration of capsule of total glucosides of paeony were applied in group E.The group C1 only received topical application of alltrans-tretioin compound and the group C2 only took oral administration of capsule of total glucosides of paeony.The clinical effects were evaluated 3 months and 6 months after application of these medicines.The clinical results were followed up for 6 months.Results A total of 107 patients completed the follow-up.The total effective rates were 78％ (29/37),75％ (27/36) and 56％ (19/34) in group E,C1,and C2 respectively after the administrations for 3 months.There was significant difference between group E and group C2 (x2 =4.094,P =0.043).No significant difference between group E and group C1 was found (x2 =0.117,P =0.733).After 6 months,the total effective rate of group E(86％) was significantly higher than that of group C1 (64％) (x2 =4.303,P =0.038) or C2 (62％) (x2 =5.722,P =0.017).Conclusions The combined application of topical all-trans retinoic acid compound and capsule of total glucosideof paeony could improve the clinical symptoms of reticular oral lichen planus.
