The relationship between adiponectin gene polymorphisms and the risk of the chronic periodontitis and diabetes mellitus
10.3760/cma.j.issn.1002-0098.2012.s1.005
- VernacularTitle:脂联素基因多态性与慢性牙周炎及2型糖尿病的相关性研究
- Author:
Jie ZHANG
1
;
Ping HUANG
;
Fan ZHANG
;
You-Juan WANG
;
Dao-Zhou LIU
;
Hua ZHANG
Author Information
1. 浙江大学医学院附属义乌医院口腔科
- Keywords:
Adiponectin;
Diabetes mellitus,type 2;
Chronic periodontitis;
Polymorphism,genetic
- From:
Chinese Journal of Stomatology
2012;47(z1):21-25
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between adiponectin gene polymorphisms and the susceptibility of the chronic periodontitis and diabetes mellitus.Methods Two hundreds patients were selected and divided into four groups,according to their physical and periodontal status.The four group were as follows,the healthy group as control,the one with chronic periodontitis,the one with type Ⅱ diabetes mellitus,and the one suffered from the both.Then,DNA was extracted from buccal mucosa swabs,and the genotype of single nucleotide polymorphism (SNP) 276 as well as SNP 45 in adiponectin gene can be obtained using polymerase chain reaction (PCR) together with restrictive fragment length polymorphism analysis.The relationship between the adiponectin gene polymorphism and chronic periodontitis and diabetes mellitus was analyzed statistically.Results There was significant difference between the normal healthy group (GG:20,GT:26,TT:4) and the diabetes mellitus group (GG:16,GT:20,TT:14) at SNP 276 (P =0.034).But there is no statistically difference between the normal healthy group (GG:26,TG:21,TT:3) and the diabetes mellitus group (GG:27,TG:22,TT:1) at SNP 45 (P =0.856).Moreover,the distribution of SNP 276 shows no difference between the normal healthy group aud the group with chronic periodontitis (GG:14,GT:30,TT:6) (P =0.418).No significant difference was found from the adiponectin haplotype analysis of SNP 45 between the normal healthy group and the group with chronic periodontitis (GG:30,TG:18,TT:2) (P =0.699).According to Logistic regression,the OR of sex is 2.938 in the chronic periodontitis group with the mellitus diabetes(P =0.011).Conclusions These results suggest that SNP 276 in the ADIPOQ gene is associated with diabetes mellitus type 2,but not with chronic periodontitis.There was no association between the adiponectin gene 45 polymorphism and diabetes mellitus type 2.Besides,neither of SNP 276 and 45 has somethiug to do with chronic periodontitis.
