Periodontal therapy improved lipoprotein-associated phospholipase A2 and lipid levels in serum of chronic periodontitis subjects with hyperlipidemia
10.3760/cma.j.issn.1002-0098.2012.s1.002
- VernacularTitle:牙周基础治疗降低高血脂伴牙周炎患者血清脂蛋白相关磷脂酶A2及血脂水平
- Author:
Shuang-Ying ZHOU
1
;
Jin-Yu DUAN
;
Xiang-Ying OUYANG
Author Information
1. 100081,北京大学口腔医学院·口腔医院牙周科
- Keywords:
Periodontitis;
Dyslipidemias;
Lipoprotein-associated phospholipase A2;
Periodontal therapy
- From:
Chinese Journal of Stomatology
2012;47(z1):6-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effect of non-surgical periodontal therapy on levels of lipoprotein-associated phospholipase A2 (LP-PLA2) and lipid profile markers in chronic periodontitis (CP)subjects with hyperlipidemia.Methods Forty CP subjects with hyperlipidemia (mean age 56.1 ± 10.3 years old,male 20,female 20) were enrolled.In addition to periodontal clinical parameters,serum concentrations of LP-PLA2,serum lipid profiles including total cholesterol (TC),triglyceride (TG),high-density lipoprotein(HDL),low-density lipoprotein (LDL),and white blood cell (WBC) counts were determined at baseline and 3 months after non-surgical periodontal therapy.Results After non-surgical periodontal therapy,all clinical parameters improved significantly [probing depth (PD):from 3.93 (3.63,4.48) mm to 2.47 (2.06,2.92) mm; clinical attachment loss:from 5.14(4.51,5.46) mm to 4.03 (3.38,4.33) mm; plaque index from 1.28 (0.94,1.61) to 0.77 (0.65,1,13) ; bleeding on probing percentage from 99.82％ (86.25％,100.00％) to 33.49％ (29.45％,43.30％) ; P ＜ 0.001.Levels of LP-PLA2,TC,TG and WBC counts were reduced significantly [LP-PLA2:from (30.06 ± 9.96) mg/L to (23.80 ± 14.76) mg/L,P =0.019; TC:from 5.57(5.26,6.25) mmol/L to 5.36(5.16,5.86) mmol/L,P =0.001 ; TG:from 1.79 (1.55,2.01) mmol/L to 1.57 (1.34,1.79) mmol/L,P ＜ 0.001 ; WBC counts:from 5.90(5.40,6.55) × 103 cell/L to 5.45(5.13,5.80) × 103 cell/L,P ＜0.001] ; HDL level increased significantly [from 1.12 (0.97,1.49) mmol/L to 1.23 (1.13,1.53) mmol/L,P =0.001] ; the reduction of LP-PLA2 (△LP-PLA2) was correlated with the reduction of PD (△PD) (r =0.367,P =0.020).Conclusions The results indicate that non-surgical treatment reduces systemic LP-PLA2 and WBC levels and improves lipid profiles.These results suggest that non-surgical periodontal therapy may reduce the risk of cardiovascular disease in some subjects with hyperlipidemia.
