Expression of lysyl oxidase gene in salivary pleomorphic adenoma
10.3760/cma.j.issn.1002-0098.2011.s1.013
- VernacularTitle:涎腺多形性腺瘤中赖氨酰氧化酶表达的研究
- Author:
Meng SONG
1
;
Cui-Cui XIAO
;
Ting-Le WANG
;
Xue-Ping OU
Author Information
1. 上海交通大学医学院附属第一人民医院
- Keywords:
Salivary gland neoplasms;
Adenoma,pleomorphic;
Lysyl oxidase
- From:
Chinese Journal of Stomatology
2011;46(z1):54-57
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of lysyl oxidase (LOX) in salivary pleomorphic adenoma.Methods The tissue samples were divided into two groups.Twenty samples of salivary gland pleomorphic adenoma tissues and twenty samples of normal parotid gland tissues adjacent to the pleomorphic adenoma were collected.The LOX gene mRNA expression was detected by reverse transcriptase polymerase chain reaction (RT-PCR) and Real-time PCR,and the alteration of expression was analysed.The LOX protein expression was then examined by western blotting.Results The salivary gland pleomorphic adenomatissue expressed more LOX gene mRNA and protein than normal salivary gland tissue.Conclusions LOX gene and protein may play a role in the tumorigenesis of salivary pleomorphic adenoma.
