Expression of Foxp3 + regulatory T cells in oral lichen planus
10.3760/cma.j.issn.1002-0098.2011.s1.008
- VernacularTitle:Foxp3+调节性T细胞在口腔扁平苔藓组织中的表达
- Author:
Yang BAI
1
;
Wen-Mei WANG
;
Xiang WANG
;
Wen-hui JIANG
;
Xiao-feng HUANG
;
Ya-Jing LIU
Author Information
1. 南京大学口腔医学院
- Keywords:
T-lymphocytes,regulatory;
Immunohistochemistry;
Lichen planus,oral;
Double staining
- From:
Chinese Journal of Stomatology
2011;46(z1):31-35
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the expression and distribution of forkhead/winged helix transcription factor p3 (Foxp3) + regulatory T cells (Treg) in oral lichen planus (OLP) and to explore the role of Foxp3 + Treg cells in the pathogenesis of OLP.Methods Immunohistochemistry double stainings ( CD4+ Foxp3 + and CD25+ Foxp3 + ) were performed on tissue sections of 35 cases of OLP,which was compared with 19 normal oral mucosa controls.A further analysis was carried out on the percentages of CD4+ Foxp3 + cells in CD4+ T cells.Results OLP biopsy samples showed a strong infiltration of CD4+ Foxp3 + Treg cell and CD25+ Foxp3 + Treg.A significantly higher frequency of CD4+ Foxp3 + Treg ( 39.58 ± 11.08 ),CD25+ Foxp3 + Treg (35.50 ± 17.74 ) per high magnification field,could be observed in OLP,compared with control group ( 1.88 ±0.51,2.5 ±0.65 respectively) (P ＜0.01 ).Whereas in OLP group,the proportion of Foxp3 + cells in CD4+T cells[ (21.11 ±8.87)％ ] was significantly lower than that in control group[ (38.89 ±8.84 )％ ] ( P ＜ 0.01 ).Between the erosive OLP group and the reticular OLP group,the quantity of CD4+ Foxp3 + Treg or CD25+ Foxp3 + Treg showed no significant difference.But in the erosive OLP group,the proportion of Foxp3 + cells in CD4+ T cells was significantly lower than that in reticular OLP group (P ＜ 0.05 ).Conclusions The imbalance between regulatory T cells and effector T cells occurs within OLP lesions,which may play a role in pathogenesis of OLP.
