The treatment of osteoporosis and bone resorption of alveoli with alendronate in rat model
10.3760/j.issn:1002-0098.2001.03.010
- VernacularTitle:阿仑膦酸钠防治牙槽骨吸收的实验研究
- Author:
Xiaomin WANG
1
;
Zongping YANG
;
Shifeng YU
Author Information
1. 北京大学医学部附属第一医院(北大医院)
- From:
Chinese Journal of Stomatology
2001;36(3):193-196
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the anti-osteoporosis effect of alendronate on bone in rat model. Methods The osteoporosis and alveolar bone resorption animal model were established in rats. The experimental groups were given alendronate in 5 mg/kg BW by subcutaneous injection after first day of ovariectomy and dental ligature, three times a week for 6 weeks. All the animals were sacrifised 12 weeks after the operation. The blood samples were collected for determination of biochemical indices. The left femora and jaw bones were processed for histomorphometry. The right femora and mendibles were prepared for determination of bone density and bone biodynamics. Results As compared with the control groups(without alendronate), the values of experimental groups (with alendronate) were all significantly improved on bone density, bone anti-flexure ability and body weight. The alkaline phosphatase, calcium in serum of ovariectomy groups(without alendronate) were obviously increased. In the experimental group, however, these indices were close to normal levels. In histomorphometry, there were little inflammation in gingiva and no obvious bone resorption in the alveolar crests of the experimental groups; but there were obvious gingivitis and alveolar crests resorption of the control groups. Conclusions Alendronate can effectively prevent bone loss to reduce osteoporosis in ovariectomized rats and prohibit pathological alveolar bone resorption.
