The effects of nifedipine on proliferation and DNA synthesis of gingival fibroblasts
10.3760/j.issn:1002-0098.2001.03.006
- VernacularTitle:硝苯地平对牙龈成纤维细胞增殖和DNA合成的影响
- Author:
Weibin SUN
1
;
Chunmei JIANG
;
Shizhong ZHENG
Author Information
1. Nanjing Medical University
- From:
Chinese Journal of Stomatology
2001;36(3):180-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of nifedipine, a calcium channel blocker, on cellular proliferation in gingival fibroblasts in vitro. Methods Gingival fibroblasts were cultured and incubated with various concentrations of nifedipine (1 200.0, 360.0,108.0 and 32.4 μg/L) for up to 7 days. 3H-TdR incorporation assay in vitro taken was used to evaluate the amount of DNA synthesis. Results Cell numbers were significantly different among these groups on sixth and seventh day, especially higher in 1 200.0 μg/L and 360.0 μg/L groups. The incorporation percentage in high concentration groups were significantly higher than those in others. Conclusion Nifedipine can influent proliferation of gingival fibroblsts in high concentration.
