Analysis of the efficacy of vocal cord botulinum toxin injection for refractory laryngeal contact granuloma
10.3760/cma.j.cn115330-20240606-00340
- VernacularTitle:声带A型肉毒素注射治疗难治性喉接触性肉芽肿的疗效分析
- Author:
Jiasen WANG
1
;
Jinrang LI
;
Yufei PAN
;
Zhi LIU
;
Chun ZHANG
;
Wenjing WANG
Author Information
1. 中国人民解放军总医院第六医学中心耳鼻咽喉头颈外科医学部咽喉嗓音外科 国家耳鼻咽喉疾病临床医学研究中心，北京 100048
- Keywords:
Laryngeal contact granuloma;
Vocal cord injection;
Botulinum toxin;
Thyroarytenoid muscle;
Therapeutic effect
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2024;59(10):1048-1053
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the efficacy of vocal cord botulinum toxin type A injection in the treatment of refractory laryngeal contact granuloma and to analyze the factors affecting the curative effect.Methods:Fifty-two patients with refractory laryngeal contact granuloma who received vocal cord botulinum toxin type A injection under topical anesthesia from May 2021 to May 2023 were analyzed retrospectively. Among them, 51 were males and 1 was female, aged 22-66 (48.98±8.87)years old. All patients were followed up for a minimum of 12 months. Outcome measures in terms of patient cure rate, total effective rate, complications and recurrence rate were calculated. The median [ M ( Q1, Q3)] was used to represent non-normally distributed measurement data, and Logistic regression analysis was used to determine independent risk factors affecting efficacy. Results:The cure rate of 52 patients with refractory laryngeal contact granuloma treated by vocal cord botulinum toxin type A injection was 78.8% (41/52), and the total effective rate (including cure, marked and effective) was 90.4% (47/52). The median number of injections was 1[1,2]. Following a single injection, the cure rate was 69.2% (36/52), and the median treatment duration for cured patients was 3 [3,3] months. Hoarseness occurred in 88.5% (46/52) of patients, with recovery within 3 months in all cases. Additionally, 21.2% (11/52) of the patients experienced cough, sore throat, dyspnea, all of whom recovered within 3 months. One patient among the 41 cured cases was lost to follow-up, and the recurrence rate at the 12th month was 17.5% (7/40). Multivariate regression analysis indicated that age, granuloma size, history of PPI treatment, previous corticosteroid injections, prior surgical excision, pharyngeal reflux, chronic cough, pharyngeal reflux, chronic cough and vocal overuse were not independent risk factors for cure and recurrence.Conclusion:Vocal cord botulinum toxin type A injection is an alternative for the treatment of refractory laryngeal contact granuloma, which offers benefits such ashigh cure rate, short treatment cycle and less injection times.
