The association of renalase single-nucleotide polymorphisms rs2576178 and rs10887800 with hypertension in patients with obstructive sleep apnea
10.3760/cma.j.cn115330-20221109-0067
- VernacularTitle:OSA患者肾胺酶基因单核苷酸多态性rs2576178和rs10887800与高血压的相关性研究
- Author:
Jundong YANG
1
;
Wenjun XUE
;
Zhicheng WEI
;
Caiqiong HOU
;
Xinyi LI
;
Huajun XU
;
Xiaolin WU
;
Yunhai FENG
;
Shankai YIN
Author Information
1. 上海交通大学医学院附属第六人民医院耳鼻咽喉头颈外科 上海市睡眠呼吸障碍疾病重点实验室，上海 200233
- Keywords:
Obstructive sleep apnea;
Renalase;
Hypertension;
Polymorphism
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2023;58(10):966-973
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To evaluate the associations between the renalase single-nucleotide polymorphisms rs2576178 and rs10887800 and the risk of hypertension in OSA patients. Methods:A total of 3, 570 male OSA subjects diagnosed via standard polysomnography were included in this retrospective study. We recorded anthropometric, genomic, and polysomnographic parameters and blood pressure levels. All subjects were divided into four groups based on quartiles of the apnea-hypopnea index (AHI). The relationships between rs2576178 and rs10887800 and the risk of hypertension were evaluated using the binary logistic regression, and haplotype analysis.Results:In the bottom AHI quartile, rs10887800 was significantly associated with the risk of hypertension according to the dominant model [odds ratio( OR)=0.691, 95% confidence interval ( CI)=0.483-0.990, P=0.044] even after adjustment for age, sex, and the body mass index. The G-A haplotype was associated with a co-effect of the two SNPs, namely, the risk of hypertension decreased ( OR=0.879, 95% CI=0.784-0.986, P=0.028). Conclusions:We find no association between single rs2576178 or rs10887800 variants with the risk of hypertension in our OSA population. But, the synergistic effect of the two polymorphisms is associated with the risk of hypertension in OSA patients.
