Predictive significance of tissue eosinophilia for nasal polyp recurrence
10.3760/cma.j.issn.1673-0860.2016.04.005
- VernacularTitle:组织嗜酸粒细胞增多对慢性鼻-鼻窦炎伴鼻息肉复发的预测价值研究
- Author:
Chengshuo WANG
1
,
2
;
Hongfei LOU
;
Yifan MENG
;
Yingshi PIAO
;
Luo ZHANG
Author Information
1. 100730 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科
2. 100005 北京市耳鼻咽喉科研究所鼻病研究北京市重点实验室
- Keywords:
Eosinophils;
Nasal polyps;
Recurrence;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2016;51(4):268-272
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the association between clinical parameters,especially tissue eosinophilia,and chronic sinusitis with nasal polyps (CRSwNP) recurrence.To identify optimal criteria of tissue eosinophilia as a predictor for recurrence.Methods Two hundred and forty-eight CRSwNP patients were enrolled in this study.The demographic and clinical features were compared between recurrence and no recurrence groups.Mucosal specimens were assessed for the presence of tissue inflammatory cells.Factors associated with polyp recurrence were analyzed by Logistic regression analysis and optimal cutoff point of the predictor for nasal polyp recurrence was determined by receiver operating characteristic curve.SPSS 19.0 software was used to analyze the data.Results The recurrence rate was 55.6％ (138/248 patients) in this cohort.Tissue and peripheral eosinophilia,comorbid asthma,olfactory score and Lund-Mackay score were significantly correlated with polyp recurrence(all P ＜ 0.01).As a predictor for recurrence,tissue eosinophil accumulation outweighed other parameters.A cutoff value of 27％ for tissue eosinophil percentage was able to predict recurrence with 96.4％ sensitivity and 92.7％ specificity (AUC =0.971,P ＜ 0.001).Conclusions Tissue eosinophilia provides valuable information regarding to polyp recurrence.Tissue eosinophil proportion equal to or over 27％ may be regarded as the prognostic criterion for nasal polyp recurrence.
