Clinical significance of the preoperative neutrophil lymphocyte ratio in the evaluation of the prognosis of laryngeal carcinoma
10.3760/cma.j.issn.1673-0860.2016.02.008
- VernacularTitle:术前中性粒细胞淋巴细胞比值对喉癌预后评估的临床意义
- Author:
Guofeng ZHAO
1
;
Yanhong HU
;
Ruli LIU
;
Feng SHI
;
Haipeng LI
;
Donghai WANG
;
Baocheng WANG
Author Information
1. 063000,唐山市协和医院耳鼻咽喉头颈外科
- Keywords:
Neutrophils;
Lymphcytes;
Laryngeal neoplasms;
Recurrence;
Neoplasms metastasis;
Prognosis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2016;51(2):112-116
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of preoperative neutrophil lymphocyte ratio (NLR) on the prognosis of patients with laryngeal carcinoma.Methods Clinical data of 202 patients with laryngeal carcinoma treated from January 2004 to October 2009 were retrospective analyzed to determine the optimal critical value of NLR.To study whether NLR is an independent factor affecting the recurrence and 5-year survival rate of patients with laryngeal cancer after surgery,single factor and multivariate analyses were performed.The factors included age,gender,T stage,pathological differentiation,lymph node metastasis,primary tumor site and NLR value.The relationship between NLR and cervical lymph node metastasis was analyzed.Results The optimal critical value of NLR was 2.85,by which cases were divided into high NLR group (NLR≥2.85) and low NLR group (NLR ＜ 2.85).Single factor and multivariate analyses indicated that T staging,lymph node metastasis,primary tumor location,and NLR were the independent factors affecting the recurrence of laryngeal carcinoma.T stage and lymph node metastasis were the independent factors affecting 5-year survival rate of laryngeal carcinoma.The increase of NLR value increased the rate of cervical lymph node metastasis.Conclusion Preoperative NLR level influences the recurrence and cervical lymph node metastasis of laryngeal carcinoma and can be considered a prognosis factor of laryngeal cancer.
