Imbalance between Th1 and Th2 cells in cord blood is influenced by maternal allergic rhinitis and associated with atopic dermatitis during the first two years of life
10.3760/cma.j.issn.1673-0860.2014.05.008
- VernacularTitle:脐带血Th1／Th2细胞失衡与母亲变应性鼻炎及婴幼儿特应性皮炎的相关性研究
- Author:
Hongfei LOU
1
,
2
;
Yujing FU
;
Chengshuo WANG
;
Yang WANG
;
Luo ZHANG
Author Information
1. 100730 首都医科大学附属北京同仁医院耳鼻咽喉头颈外科
2. 北京市耳鼻咽喉科研究所鼻病研究北京市重点实验室
- Keywords:
Rhinitis,allergic,perennial;
Dermatitis,atopic;
Fetal blood;
Interferon type Ⅱ;
Interleukin-4
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2014;(5):390-394
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of maternal atopy on cord blood effector T cells and to identify these biologic markers as predictors of atopic dermatitis ( AD).Methods Seventy mother-infant pairs were recruited in this prospective birth cohort study.Suspected factors for allergy , including maternal allergic history , total serum IgE , and maternal age at birth , were collected.Mother peripheral blood samples and cord blood were obtained and assayed for the percentage of interferon -γ( IFN-γ) and interlukin 4 (IL-4) producing T cells(Th1 and Th2 respectively) using flow cytometry.Their offspring at the age of 2 years old were evaluated by their dermatologist whether they had AD.Statistical analysis was performed using multiple logistic regression models and receiver-operating characteristic curve was employed to predict atopic dermatitis.Results Twenty-one allergic and 49 nonallergic mothers were recruited in this study.During the first two years of life, 15.7%children (n=11) developed a physician-diagnosed AD (all children were the only child in the family ).In group with maternal allergic rhinitis , a significantly increased percentage of Th2 was observed in peripheral blood of mother ( 7.10 [ 1.18;16.1 ]% vs.0.37 [ 0.25;0.72]%, U=10.0, P <0.05 ) and cord blood of newborns ( 1.02 [ 0.57;1.34 ]% vs.0.21 [ 0.15;0.42]%, U=127.5, P<0.05), respectively.Maternal atopic history did not affect the percentage of Th1cells in cord blood (0.69[0.40;1.12]% vs.0.50[0.31;0.66]%, U=361.0, P>0.05).Children with reduced Th1/Th2 ratio in cord blood had a higher risk to develop AD (OR=1.72,P=0.001).The model including Th1/Th2, maternal allergy, maternal age at birth and maternal total IgE showed high ability to discriminate children with and without AD.AUC was 0.907 (95% CI:0.804 -1.011, P<0.001).Conclusions Elevated IL-4 +CD4 +T cells in cord blood were of relevance with maternal allergic history.Imbalance between Th1 cell and Th2 cell at birth are associated with maternal allergy and promoted subsequent AD development.
