Observation the clinical curative effect of children′s laryngopharyngeal reflux and sleep apnea hypopnea syndrome
10.3760/cma.j.issn.1673-0860.2014.05.006
- VernacularTitle:并发咽喉反流的睡眠呼吸暂停低通气综合征儿童临床治疗初步观察
- Author:
Shan CHEN
1
;
Lan LI
Author Information
1. 518000,深圳市儿童医院耳鼻咽喉科
- Keywords:
Sleep apnea,obstructive;
Laryngopharyngeal reflux;
Child;
Drug therapy
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2014;(5):379-383
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the clinical curative effect of anti-reflux treatment for obstructive sleep apnea hypopnea syndrome ( OSAHS) in children.Methods Twenty children with sleep-disordered breathing were included in this study .There were 15 males and 5 females, aged 3-9 years old, median 6 years old.The electronic laryngoscope, polysomnography (PSG) monitoring, Reflux symptom index (RSI) questionnaire and Reflux finding score ( RFS) were used to establish the initial diagnosis of OSAHS with LPRD,preclud adenoid hypertrophy and tonsil hypertrophy and nasal disorderes .Oral Domperidone and Omeprazole were given for treatment .For children under 3-year-old, the dosage of Domperidone was 0.6 ml · kg -1 · day -1 .For children over 3-year-old, Domperidone combined with Omeprazole were given with the dosage of 0.3 mg· kg-1 · day -1.Results After 4 weeks of treatment,19 patients symptoms of OSAHS include disturbed sleep , dyspnoes and apneic attack improved .After 8 weeks of treatment , 20 cases with OSAHS symptoms improved than before treatment .Under the electronic laryngoscope , the decrease in pharyngeal lymphoid follicles , the epiglottis , aryepiglottic fold and scoop intergenic region erythema shallow , edema lessened.After treatment of 4 weeks and 8 weeks, there was statistically significant (P<0.05). Before and after treatment, the difference of RFS was statistically siginificant (P<0.05); PSG monitoring proved significant effect in 3 cases(15.0%), effective in 11 cases (55.0%) and 6 cases were ineffective (30.0%).Twenty patients with obstructive apnea index change was not obvious ( P >0.05 ), apnea hypopnea index and lowest artery oxygen saturation better , differences were statistically significant ( Z of 2.819 and 2.733 respectively, P<0.05).Conclusion The treatment of LPRD can improve the symptoms of OSAHS, these two diseases may coexist in mutual relations .
