1H-MRS study of auditory cortex in patients with presbycusis
10.3760/cma.j.issn.1673-0860.2012.10.013
- VernacularTitle:老年性聋患者听皮层磁共振波谱分析
- Author:
Xian-Ming CHEN
1
;
Xiao-Qing DOU
;
Yong-Hui LIANG
;
Li-Wei ZHANG
;
Bi-Qiang LUO
;
Yi-Hong DENG
Author Information
1. 南京军区福州总医院
- Keywords:
Presbycusis;
Auditory cortex;
Magnetic resonance spectroscopy
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2012;47(10):852-855
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the metabolic changes of auditory cortex in patients with presbycusis by using proton magnetic resonance spectroscopy(1H-MRS). Methods Ten normal hearing volunteers(youth group),10 normal hearing of elderly (aged group) and 8 patients with presbycusis (presbycusis group ) were checked with proton magnetic resonance spectroscopy. N-acetylaspartic acid ( NAA),creatine ( Cr),choline ( Cho),γ-aminobutyric acid (GABA),glutamic acid ( Glu ) compound were measured.The differences between the groups were semi-quantitatively analyzed.Results When compared with youth group,reduced NAA/Cr,increased Cho/Cr were found in the aged group and presbycusis group (P ＜ 0.05 ). GABA/Cr ratio and Glu/Cr ratio were significant difference between presbycusis group and youth group(P ＜ 0.05 ). There were no significant difference in the GABA/Cr and Glu/Cr ratios in the bilateral auditory cortex between the youth group and the aged group(P ＞ 0.05 ).When compared with aged group,the metabolic changes of auditory cortex in patients with presbycusis were remarkable ( P ＜ 0.05 ).Conclusions 1H-MRS is a noninvasive technique that can provide useful information concerning the metabolic changes of auditory cortex in human. In comparison to the aged group and the youth group,the changes of NAA,GABA,Cho and Glu is found in auditory cortex in patients with presbycusis.
