Clinical application analysis of methotrexate in the treatment of children with acute lymphoblastic leukemia

VernacularTitle:甲氨蝶呤治疗儿童急性淋巴细胞白血病的临床应用分析
Author: Wen-Jun CAI ¹ ; Zi-Ning WANG ; Chao-Yang CHEN ; Ying ZHOU
Author Information

1. 北京大学第一医院药剂科,北京 100034
Keywords: methotrexate; children with acute lymphoblastic leukemia; CiteSpace; visualization analysis; bibliometric analysis
From: The Chinese Journal of Clinical Pharmacology 2024;40(19):2901-2904
CountryChina
Language:Chinese
Abstract: Objective To analyze the literature on methotrexate(MTX)in the treatment of children with acute lymphoblastic leukemia(ALL)from the perspective of bibliometric analysis,and to understand the research status and future research trend.Methods Literature related to MTX treatment of children with ALL was retrieved from CNKI,and CiteSpace 6.1.R6 Advanced software was applied to the literature for trend of number of publications,keyword co-occurrence,keyword clustering and keyword emergence.Results A total of 205 literatures were included,and the number of published papers fluctuated.The main research hotspots of using MTX to treat children with ALL were"high-dose administration"and"adverse drug reactions",and future research trends will focus on"gene detection"and"therapeutic drug monitoring(TDM)".Conclusion MTX played an important role in the treatment of children with ALL,and research on MTX treatment for children with ALL focused on high-dose administration and adverse drug reactions of MTX in recent years.