Research status of traditional Chinese medicine in regulating the cGAS-STING signaling pathway in anti-tumor therapy
10.13699/j.cnki.1001-6821.2024.18.030
- VernacularTitle:中医药调控cGAS-STING信号通路在抗肿瘤中的研究现状
- Author:
Ke-Ya WANG
1
;
Jun-Wei QI
;
Tong ZHANG
;
Tian-Le FU
;
Xiao LI
Author Information
1. 山东中医药大学医学院,山东济南 250355
- Keywords:
active ingredients of traditional Chinese medicine;
cCAS-STING signaling pathway;
anti tumor;
mechanism of action;
development of traditional Chinese medicine
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(18):2752-2756
- CountryChina
- Language:Chinese
-
Abstract:
With the aging and changes in living conditions,the incidence rate and mortality of tumors have been rising rapidly,which has become a hot topic in the medical field.At present,the treatment methods or tumors are also improving day by day,mainly relying on surgical resection.However,the characteristics of fast tumor metastasis and spread,as well as complex growth locations,make the surgical resection method limited.More and more people choose drug targeted therapy for tumors in order to reduce surgical side effects,among which cyclic guanosine monophosphate synthase interferon gene stimulatory factor(cGAS-STING signaling pathway)plays an important role in the occurrence,proliferation,and survival of tumor cells.At present,there are many types of drugs used to treat tumors,but most of them have limited control over tumor spread.In order to study the role of traditional Chinese medicine in tumor treatment and leverage its multi-component,multi target,and multi pathway characteristics,this article comprehensively analyzes and summarizes the treatment of tumors using traditional Chinese medicine based on the cGAS-STING signaling pathway in recent years,in order to further study the mechanism of action of traditional Chinese medicine and its active ingredients in the cGAS-STING signaling pathway,it also provides ideas for clinical research on new drugs.
