Research status on the mechanism of action of Astragaloside Ⅳ on cardiovascular diseases
10.13699/j.cnki.1001-6821.2024.17.026
- VernacularTitle:黄芪甲苷对心血管疾病的作用机制研究状况
- Author:
Er-Dan XIN
1
,
2
;
Yu-Gui ZHANG
;
Tian-Tian BIAN
;
Ding-Cai MA
;
Zhe WANG
;
Mao-Mao WANG
;
Yue-Feng LI
Author Information
1. 甘肃中医药大学,药学院
2. 甘肃中医药大学附属医院甘肃省中药炮制及质控工程技术研究中心,甘肃兰州 730000
- Keywords:
Astragaloside Ⅳ;
cardiovascular disease;
inflammatory response;
cell apoptosis;
myocardial ischemia reperfusion injury;
lipid metabolism;
myocardial fibrosis
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(17):2580-2585
- CountryChina
- Language:Chinese
-
Abstract:
Asragaloside Ⅳ(AS-Ⅳ)is one of the active ingredients of Astragalus membranaceus,and AS-Ⅳ can play a protective role in cardiovascular diseases by inhibiting inflammatory response,inhibiting cardiomyocyte apoptosis,improving myocardial ischemia reperfusion injury,regulating lipid metabolism,promoting cardiac vascular regeneration,inhibiting myocardial fibrosis,and improving myocardial hypertrophy.In this paper,we reviewed the relevant literature on the prevention and treatment of cardiovascular diseases of AS-Ⅳ,and summarized and analyzed its role and mechanism,in order to provide a reference for the in depth research on cardiovascular diseases and the development and application of drugs.
