Research status of esketamine and postoperative cognitive dysfunction
10.13699/j.cnki.1001-6821.2024.16.031
- VernacularTitle:艾司氯胺酮与术后认知功能障碍的研究现状
- Author:
Shi-Long GAO
1
;
Xue-Cheng HAN
;
Wen-Hu MA
;
Xue-Jun WANG
Author Information
1. 青海红十字医院麻醉科,青海西宁 810000
- Keywords:
esmolamine;
postoperative cognitive impairment;
perioperative neurocognitive impairment
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(16):2447-2451
- CountryChina
- Language:Chinese
-
Abstract:
Objective As a new type of N-methyl-D-aspartic acid(NMDA)receptor antagonist,esmolamine has the same pharmacological mechanism and site as ketamine,but its affinity to NMDA receptor is 3-4 times that of ketamine,and its analgesic effect is 2-2.5 times that of ketamine.Postoperative cognitive dysfunction is the most common complication in elderly patients undergoing anesthesia and surgery.The incidence is higher in elderly patients over 65 years old,which seriously affects the quality of postoperative recovery and increases the medical burden.It is one of the clinical problems to be solved urgently.In recent years,with the clinical application of esmolamine,it has been found that intraoperative use of esmolamine can make the hemodynamics of surgical patients more stable,reduce the release of inflammatory factors and reduce the incidence of postoperative cognitive impairment.This article reviews the research progress of the effect of esmolamine on postoperative cognitive dysfunction in the field of clinical and basic research at home and abroad,in order to provide clinical reference.
