Research status of mechanisms of pancreatic islet beta cell injury in type 2 diabetes

VernacularTitle:2型糖尿病胰岛β细胞损伤机制的研究现状
Author: Yan-Hui ZHAI ¹ ; Yong-Lin LIANG ; Dong AN ; Yuan-Yuan ZHANG ; Fei SU ; Xiao-Wen GUAN ; Xiang-Dong ZHU
Author Information

1. 甘肃中医药大学基础医学院,甘肃兰州 730000
Keywords: type 2 diabetes; pancreatic β cells; damage mechanism
From: The Chinese Journal of Clinical Pharmacology 2024;40(16):2442-2446
CountryChina
Language:Chinese
Abstract: The number of type 2 diabetes(T2DM)accounts for more than 90％of all Diabetes mellitus(DM).The decrease of islet β cell mass and dysfunction are the core links of T2DM.With the prolongation of the course of disease,the number and function of β cells are gradually attenuated,and the damage mechanism has not been elucidated.At present,it is believed that it is closely related to metabolic stress,abnormal regulation of insulin secretion,changes in islet microenvironment,mitochondrial damage,glycolipid toxicity and dedifferentiation of islet β cells.Therefore,the mechanism of islet β cell damage in T2DM is summarized and elaborated in order to provide some reference for the precise intervention of T2DM.