Research status of mechanism of psilocybin in the treatment of treatment-resistant depression
10.13699/j.cnki.1001-6821.2024.16.027
- VernacularTitle:赛洛西宾治疗难治性抑郁症机制的研究现状
- Author:
Guang-Shun HUA
1
;
Chen-Yang GUO
;
Hang ZHANG
;
Yu-Ting GUO
;
Si-Miao GONG
;
Yan YANG
Author Information
1. 成都中医药大学养生康复学院,四川成都 610075
- Keywords:
psilocybin;
treatment-refractory depression;
5-hydroxytryptamine 2A receptor;
neuronal plasticity;
signaling pathway
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(16):2428-2432
- CountryChina
- Language:Chinese
-
Abstract:
Refractory depression is a drug-resistant subtype of major depressive disorder for which there is a lack of effective and durable treatments.Seroxibine,the active substance in the mushroom Capsicum annuum,is a natural 5-hydroxytryptamine hallucinogen that activates the 5-hydroxytryptamine 2A receptor to mediate multiple aspects of antidepressant effects.In recent years,it has received renewed attention for its outstanding therapeutic effects in the treatment of refractory depression or other psychiatric disorders.Therefore,this paper summarizes the studies on neuroplasticity,brain neural connectivity network,neurotransmitters,immune factors,microbiota-gut-brain axis,and clinical efficacy of seloxipine in domestic and international literature,and explores the possible mechanisms of seloxipine's effect on refractory depression,with a view to providing theoretical basis for the clinical application of this drug.
