Research status of the correlation between ferroptosis and renal fibrosis
10.13699/j.cnki.1001-6821.2024.15.027
- VernacularTitle:铁死亡与肾纤维化相关性的研究现状
- Author:
Li-Juan LIANG
1
,
2
,
3
;
En-Lai DAI
;
Jun-Yuan BAI
;
Can LIU
;
Zhao-Ran DING
;
Jie ZHANG
Author Information
1. 甘肃中医药大学第一临床医学院,甘肃兰州 730100
2. 甘肃中医药大学中西医结合学院,甘肃兰州 730100
3. 敦煌医学与转化教育部重点实验室,甘肃兰州 730100
- Keywords:
ferroptosis;
renal fibrosis;
chronic kidney disease;
pathogenesis;
treatment
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(15):2278-2282
- CountryChina
- Language:Chinese
-
Abstract:
Renal fibrosis is a common pathological manifestation of all chronic kidney diseases.Ferroptosis is closely related to the pathogenesis of renal fibrosis and can influence the onset of renal fibrosis,and it is the most critical step in the development of renal fibrosis.The paper describes the relationship between ferroptosis and renal fibrosis,discusses the research progress of ferroptosis on renal fibrosis,and further summarizes,analyzes,and describes the effective and highly targeted natural active ingredients of traditional Chinese medicines against ferroptosis,and concludes that the reversal of renal fibrosis is achieved through the regulation of the key targets of ferroptosis,with a view to providing a broad new direction for its prospects in the field of renal fibrotic disease prevention and treatment;and to provide a scientific guide for clinical treatment and basis for clinical treatment.
