Research status of AQP5 regulation of programmed cell death in chronic obstructive pulmonary disease
10.13699/j.cnki.1001-6821.2024.14.027
- VernacularTitle:AQP5调控细胞程序性死亡在慢性阻塞性肺疾病中的研究现状
- Author:
Cheng-Cai YUN
1
;
Li-Ying ZHANG
;
Hong-Dou HOU
;
Huan-Huan ZHANG
;
Zhang-Bo SONG
;
Wen-Xing YONG
Author Information
1. 甘肃中医药大学中西医结合学院,甘肃兰州 730000
- Keywords:
aquaporin 5;
chronic obstructive pulmonary disease;
programmed cell death;
research status
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(14):2134-2138
- CountryChina
- Language:Chinese
-
Abstract:
Aquaporin 5(AQP5),as the main water transport protein in the body,can regulate lung diseases by regulating airway mucus secretion,pulmonary inflammation,and lung function.Programmed cell death(PCD)plays a crucial role in chronic obstructive pulmonary disease(COPD).AQP5 may affect the development of COPD by regulating PCDs.This article reviews the molecular regulatory mechanism of AQP5 on apoptosis,autophagy,iron death and pyroptosis in PCDs in recent years,and further discusses its effect on COPD in order to provide theoretical support for clinical prevention and treatment of COPD.
