Effects of radiation on pharmacokinetics
10.13699/j.cnki.1001-6821.2024.13.031
- VernacularTitle:辐射对药代动力学的影响
- Author:
Jie ZONG
1
;
Hai-Hui ZHANG
;
Gui-Fang DOU
;
Zhi-Yun MENG
;
Ruo-Lan GU
;
Zhuo-Na WU
;
Xiao-Xia ZHU
;
Xuan HU
;
Hui GAN
Author Information
1. 军事医学研究院辐射医学研究所,北京 100850
- Keywords:
pharmacokinetics;
radiation;
dynamic parameter;
drug metabolizing enzyme
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(13):1996-2000
- CountryChina
- Language:Chinese
-
Abstract:
Radiation mainly comes from medical radiation,industrial radiation,nuclear waste and atmospheric ultraviolet radiation,etc.,radiation is divided into ionizing radiation and non-ionizing radiation.Studying the effects of ionizing and non-ionizing radiation on drug metabolism,understanding the absorption and distribution of drugs in the body after radiation and the speed of elimination under radiation conditions can provide reasonable guidance for clinical medication.This article reviews the effects of radiation on the pharmacokinetics of different drugs,elaborates the changes of different pharmacokinetics under radiation state,and discusses the reasons for the changes.
