Research status of regulating aerobic glycolysis by traditional Chinese medicine in prevention and treatment of lung cancer

VernacularTitle:中医药调控有氧糖酵解防治肺癌的研究现状
Author: Mao-Fu ZHANG ¹ ; Yu-Chan CHEN ; Zhong-Yang SONG ; Lu-Lu CHEN ; Hai-Hong ZHAO ; Zhi-Ming ZHANG
Author Information

1. 甘肃中医药大学中医临床学院,甘肃兰州 730000
Keywords: traditional Chinese medicine; aerobic glycolysis; lung cancer; research progress
From: The Chinese Journal of Clinical Pharmacology 2024;40(13):1982-1985
CountryChina
Language:Chinese
Abstract: Aerobic glycolysis(AEG),as the main pathway of energy metabolism of various malignant tumor cells,is involved in the whole process of the occurrence and development of lung cancer,and plays a key role in inducing tumor proliferation,invasion and metastasis.Traditional Chinese medicine monomers and compounds can regulate the expression of related signaling pathways and key proteases and genes by interfering with AEG pathway,promote the apoptosis of lung cancer cells,inhibit the AEG process and the proliferation and growth of lung cancer cells,and thus play an anti-tumor role.Based on this,this paper summarized the biological function of AEG,the mechanism of regulating lung cancer and the intervention mechanism of traditional Chinese medicine,in order to provide new ideas and scientific basis for the development of clinical drugs for lung cancer.