Immunoinfiltration correlation analysis of secreted phosphoprotein SPP1 in multiple tumors
10.13699/j.cnki.1001-6821.2024.13.025
- VernacularTitle:分泌性磷酸蛋白SPP1在多种肿瘤的免疫浸润相关性分析
- Author:
Jie CHEN
1
,
2
;
Lin CHEN
;
Yan-Lun GU
;
Mo ZHANG
;
Zhan-Yu MEN
;
Lu WANG
;
Xiao-Cong PANG
Author Information
1. 徐州医科大学药学院,江苏徐州 221009
2. 北京大学第一医院临床药理研究所,北京 100034
- Keywords:
secreted phosphoprotein 1;
macrophage;
immunoinfiltration;
extracellular matrix;
pan-cancer analysis
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(13):1968-1971
- CountryChina
- Language:Chinese
-
Abstract:
Objective To utilize bioinformatic approaches to elucidate the correlation between secreted phosphoprotein 1(SPP1)and immune infiltration in various malignancies,elucidating the mechanism of gene function in cancer-immune cell interplay.Methods Cancer samples were derived from the Cancer Genome Atlas(TCGA)and Genotype-tissue Expression(GTEx)database,examining SPP1 expression difference between tumors and normal tissues using Gene Expression Profiling Interactive Analysis(GEPIA2),and its correlation with different immune cells in extracellular matrix via TIMER2 Database.SPP1's association with interacting molecules was scrutinized on the STRING website,followed by assessment of its distinct functional state across various cancers from Cancer Single-cell State Atlas Database(Cancer SEA).Results In 32 tumor types,SPP1 mRNA is significantly elevated in 23 types of cancers and correlates heavily with fibroblast,integrin family,and CD44.Furthermore,the SPP1 gene exhibits profound specificity in tumor functions such as vascular invasion,metastasis,DNA damage,and repair.Conclusion Specific expression of SPP1 in tumors signifies a significant correlation with tumor immune cells in the extracellular matrix,promoting tumor progression and invasion.This suggests that targeted monitoring of SPP1 could serve as a prospective cancer diagnostics/therapeutics biomarker.
