Research status on the pathogenesis of diabetic peripheral neuropathy by long chain non-coding RNAs
10.13699/j.cnki.1001-6821.2024.11.030
- VernacularTitle:长链非编码RNA在糖尿病周围神经病变发病机制中的研究现状
- Author:
Shi-Ting CHEN
1
;
Ying-Xiu MEI
;
Ming-Zhu CHEN
;
Lian DU
Author Information
1. 成都中医药大学基础医学院,四川 成都 611137
- Keywords:
long chain non-coding RNA;
diabetic peripheral neuropathy;
pathogenesis;
metabolic disorders;
oxidative stress
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(11):1679-1683
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic peripheral neuropathy(DPN)is a group of neurodegenerative diseases involving the peripheral nervous system.Long chain non-coding RNA(lncRNA)is an important regulatory factor in normal life activities and disease development,widely involved in gene expression regulation,epigenetic regulation,transcription and control and other biological processes.In recent years,a large number of studies have found that lncRNAs can affect the development of DPN by participating in the pathogenesis of DPN such as metabolic disorders,oxidative stress,neuroinflammation,vascular damage,cell autophagy,apoptosis and so on.This paper elaborates on the regulatory role of lncRNAs in the pathogenesis of DPN,with a view to providing scientific references and new ideas for clinical research.
