Pathological mechanism of hypoxia-inducible factor-1α in tumours and the current status of research on Chinese medicine intervention
10.13699/j.cnki.1001-6821.2024.11.028
- VernacularTitle:缺氧诱导因子-1α在肿瘤中的病理机制及中药干预的研究现状
- Author:
Yu LIU
1
;
Li-Ying ZHANG
;
Guo-Xiong HAO
;
Ya-Feng QI
;
Qian XU
;
Ye-Yuan LIU
;
Chao YUAN
;
Peng ZHU
;
Yong-Qi LIU
;
Zhi-Ming ZHANG
Author Information
1. 甘肃中医药大学甘肃省高校重大疾病分子医学与中医药防治研究重点实验室,甘肃兰州 730000
- Keywords:
Chinese medicine;
hypoxia-inducible factor-1α;
tumour;
hypoxia
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(11):1670-1674
- CountryChina
- Language:Chinese
-
Abstract:
Traditional Chinese medicine can regulate the hypoxia-inducible factor-1α(HIF-1α)signalling pathway and slow down tumour progression mainly by inhibiting tumour angiogenesis,glycolysis,epithelial mesenchymal transition and other pathological processes.This paper,starting from HIF-1α and related factors,reviews its pathological mechanism in tumours and the research of traditional Chinese medicine interventions with the aim of providing theoretical references for the treatment of tumours with traditional Chinese medicine.
