Pafolacianine,optical imaging agents for intraoperative tumor detection

VernacularTitle:用于术中肿瘤检测的光学成像剂——帕叶昔宁钠
Author: Zhao WANG ^{1
,

2} ; Chao-Yang CHEN ; Ran WEI ; Xuan-Ling ZHANG ; Xiao-Juan HU ; Ying ZHOU
Author Information

1. 北京大学第一医院药剂科,北京 100034
2. 北京大学第一医院宁夏妇女儿童医院药剂科,宁夏回族自治区银川 750001
Keywords: pafolacianine; optical imaging agent; ovarian cancer; lung cancer
From: The Chinese Journal of Clinical Pharmacology 2024;40(11):1658-1660
CountryChina
Language:Chinese
Abstract: Pafolacianine is a fluorescent agent that specifically targets folate receptors,employed in the treatment of adult ovarian cancer patients to support the detection of malignant growths during surgical interventions.Pafolacianine binds to cancer cells expressing folate receptors,accumulating within folate-receptor-positive tumor tissue through receptor-mediated endocytosis.It can be excited by near-infrared fluorescence imaging,facilitating the surgical removal of tumors during procedures.This article gives an introduction to the mechanism of action,pharmacokinetics,clinical studies,and safety aspects of Pafolacianine.