68 Ga-DOTATOC,a new diagnostic agent for localization of somatostatin receptor positive neuroendocrine tumors
10.13699/j.cnki.1001-6821.2024.11.024
- VernacularTitle:用于诊断生长抑素受体阳性神经内分泌肿瘤的新药——68 Ga-DOTATOC
- Author:
Si-Miao ZHAO
1
;
Chao-Yang CHEN
;
Ran WEI
;
Xuan-Ling ZHANG
;
Ying ZHOU
Author Information
1. 北京大学第一医院药剂科,北京 100034
- Keywords:
68 Ga-DOTATOC;
radiopharmaceutical agent;
somatostatin receptor positive neuroendocrine tumor
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(11):1654-1657
- CountryChina
- Language:Chinese
-
Abstract:
68Ga-DOTATOC injection is a radiopharmaceutical agent for positron emission tomography localization of somatostatin receptor positive neuroendocrine tumors(NETs)in adult and pediatric patients.68 Ga-DOTATOC binds to cells that express somatostatin receptors(SSTRs),including malignant neuroendocrine cells that overexpress SSTR2 receptor.Gallium-68 is a radionuclide used in positron emission tomography for tumor diagnosis.This paper introduces its the mechanism of action,pharmacokinetics,usage and dosage,clinical evaluation,safety and use in specific populations.
