Research status of research on the role of thioredoxin 1 in cerebral ischemia

VernacularTitle:硫氧还蛋白-1在脑缺血中作用的研究现状
Author: Huai-Yu LIU ^{1
,

2} ; Ke WANG ; Wen-Jing YAN ; Yue WANG ; Wen-Xin ZHANG ; Zhi HE
Author Information

1. 三峡大学国家中医药管理局中药药理科研三级实验室,湖北宜昌 443002
2. 三峡大学健康医学院,湖北宜昌 443002
Keywords: thioredoxin-1; cerebral ischemia; thioredoxin interacting protein; neuroprotection; mechanism of action
From: The Chinese Journal of Clinical Pharmacology 2024;40(10):1525-1529
CountryChina
Language:Chinese
Abstract: Thioredoxin-1(Trx-1)is a petite redox protein primarily encountered in mammalian cells.It responds to alterations in the redox environment by facilitating electron transfer and regulating associated proteins.This paper provides a concise overview of Trx-1,focusing on its altered expression patterns during cerebral ischemia.The emphasis is on its neuroprotective attributes following cerebral ischemia,encompassing anti-oxidation,anti-inflammation,anti-apoptosis,promotion of cell growth,angiogenesis,and its involvement in cerebral ischemia-related pathologies.