Research progress on Buyang Huanwu Decoction in preventing and treating vascular dementia by regulating inflammatory factors
10.13699/j.cnki.1001-6821.2024.05.025
- VernacularTitle:补阳还五汤通过调节炎症因子防治血管性痴呆的研究进展
- Author:
Yan-Hong LIU
1
;
Shu-Yuan CONG
;
Feng WU
;
Ke-Wu ZHAO
;
Xiao-Hong DONG
;
Ning ZHANG
;
Bin LIU
Author Information
1. 黑龙江中医药大学基础医学院,黑龙江哈尔滨 150040
- Keywords:
Buyang Huanwu Decoction;
vascular dementia;
inflammation;
pharmacological action;
clinical research
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(5):749-753
- CountryChina
- Language:Chinese
-
Abstract:
Objective Vascular dementia(VD)is a clinical syndrome caused by various cerebrovascular diseases,including ischemic,hemorrhagic,and acute and chronic hypoxic cerebrovascular diseases,leading to impaired brain function and affecting patients'cognitive ability,daily life,and work abilities.Vascular dementia is a preventable and reversible form of dementia,second only to Alzheimer's disease as the second common cause of dementia.At present,the relevant pathogenesis of vascular dementia is not clear,and there is no clear treatment method.However,its pathogenesis may be related to neuroinflammation,oxidative stress,neuronal damage and white matter lesions.Its main risk factors include genetic factors,hypercholesterolemia,diabetes,hypertension,etc.Neuroinflammatory response plays a major role in the process of secondary brain injury caused by cerebral ischemia,and inflammatory factors lead to an inflammatory cascade reaction that exacerbates damage to the nervous system.Inhibiting the inflammatory pathway and reducing the expression of inflammatory factors can improve the symptoms of vascular dementia patients and animal models,indicating that neuroinflammation may play an important role in the pathogenesis of vascular dementia.This article explores the effects of Buyang Huanwu Decoction on inflammatory factors from the perspective of summarizing relevant literature in recent years.It mainly reviews the pharmacological effects of Buyang Huanwu Decoction on treating vascular dementia,the relationship between inflammatory factor levels and vascular dementia,and the prevention and treatment of vascular dementia by regulating inflammatory factor levels.
