Research status of small ubiquitin-like molecules modification in lung development
10.13699/j.cnki.1001-6821.2024.04.031
- VernacularTitle:小泛素样分子化修饰在肺发育进程中的研究现状
- Author:
Shu-Ya GUO
1
;
Cui-Ling YANG
Author Information
1. 天津中医药大学研究生院,天津 301617
- Keywords:
small ubiquitin-like modifier;
lung development;
regulatory factor;
transcriptional regulation
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(4):624-628
- CountryChina
- Language:Chinese
-
Abstract:
Small ubiquitin-like molecules(SUMO)regulate the function of a variety of cells by binding to target proteins.SUMO modification plays an important role in embryonic development,including heart,brain,liver,etc.Factors involved in lung development and maturation are regulated by SUMO modification,such as hypoxia-inducible factor,CCAAT enhancer-binding protein α,forkhead box protein M1,vascular endothelial-derived growth factor,and bone morphogenetic protein 4,thus affecting their activities and stabilities.Therefore,the SUMO modification status of target protein is the key to explore the development process of fetal lung.In this paper,we reviewed the research literature of SUMO mediated lung development in recent years,and combined with the research basis of our research group for many years,reviewed the factors regulating lung development and the SUMO status,in order to provide ideas for the study of drugs for effective prevention and treatment of pulmonary dysplasia.
