Role of TGF-β/Smads signaling pathway in myocardial fibrosis of heart failure and research status of traditional Chinese medicine intervention
10.13699/j.cnki.1001-6821.2024.03.029
- VernacularTitle:TGF-β/Smads信号通路在心力衰竭心肌纤维化中的作用及中医药干预研究现状
- Author:
Yao-Hui HUO
1
;
Jing ZHANG
;
Li-Rong ZHOU
;
Xiao-Gang ZHANG
;
Yong-Ze GAO
;
Li-Ming LIU
;
Kai LIU
Author Information
1. 甘肃中医药大学中西医结合学院,甘肃兰州 730000
- Keywords:
traditional Chinese medicine;
transforming growth factor-β/Smads signaling pathway;
heart failure;
myocardial fibrosis;
mechanism of action
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(3):444-448
- CountryChina
- Language:Chinese
-
Abstract:
During the progression of heart failure(HF),abnormal transduction of the transforming growth factor-β(TGF-β)/Smads signaling pathway is important mechanism of myocardial fibrosis(MF)in HF.TGF-β,a key factor in MF,is in an overexpression state in the process of MF in HF,and Smads is a major effector downstream of TGF-β.The TGF-β/Smads pathway induces abnormal proliferation of myofibroblasts,aggravates myocardial extracellular matrix deposition,and reduces the ability of the cardiac tissues to resist fibrosis,which plays a complex role in the pathogenesis of MF in HF.Traditional Chinese medicine(TCM)has the efficacy of unequivocal inhibiting myocardial collagen deposition,anti-MF,protecting the myocardium and improving cardiac function in the prevention and treatment of MF in HF and so on,and the TGF-β/Smads pathway is one of the key pathways through which TCM monomers,TCM combinations,and proprietary medicines can exert their cardioprotective effects on the HF.This paper reviews the existing experimental research results of TCM intervening in the TGF-β/Smads pathway for the treatment of MF in HF over the past 10 years,with a view to providing theoretical basis for the prevention and treatment of HF MF well as the development and of new drugs.
