Research status in immunotherapy of colitis-related cancer with MDSCs

VernacularTitle:靶向MDSCs免疫治疗结肠炎相关性癌症的研究现状
Author: Jia CHEN ¹ ; Qi XIA ; Yu-Jie HE ; Yue LI ; Ze-Ting YUAN ; Pei-Hao YIN
Author Information

1. 成都中医药大学医学与生命科学学院,四川成都 610075
Keywords: colitis-related cancer; myeloid-derived suppressor cells; immunotherapy
From: The Chinese Journal of Clinical Pharmacology 2024;40(2):294-298
CountryChina
Language:Chinese
Abstract: Colitis-associated cancer(CAC)is a specific type of colorectal cancer that develops from inflammatory bowel disease(IBD).Myeloid-derived suppressor cells(MDSCs)are a group of myeloid cells with immunosuppressive properties,and MDSCs in the tumor microenvironment proliferate and activate during the development of colitis-associated cancer,inhibiting T-cell production and impairing their function,which impedes the immunotherapeutic effect of colitis-associated cancer.In this paper,we review the immunosuppressive mechanisms of MDSCs in the development of inflammatory bowel disease to colitis-associated cancers and the current drugs targeting MDSCs for immunotherapy of inflammatory colorectal cancers,with a view to providing new strategies for the treatment of colitis-associated cancers.