Establishment of animal model of increased renal solute clearance

VernacularTitle:肾溶质清除率增加高发疾病动物模型建立研究
Author: Shu YANG ¹ ; Yi-Fan LUO ; Yang CHU
Author Information

1. 中国医科大学第一临床学院,辽宁沈阳 110001
Keywords: augmented renal clearance; animal models; sepsis; burn; subarachnoid hemorrhage; traumatic brain injury
From: The Chinese Journal of Clinical Pharmacology 2024;40(1):135-138
CountryChina
Language:Chinese
Abstract: Clinically common patients with severe diseases such as sepsis,burns,subarachnoid hemorrhage,and traumatic brain injury have increased renal solute clearance,it's called augmented renal clearance(ARC).When such patients are given drugs that are excreted mainly by the kidneys,the drug does not reach effective therapeutic concentration levels,thereby increasing the risk of treatment failure.In recent years,this phenomenon has attracted more and more attention,but because its mechanism is not clear,it also limits the development of animal models for ARC research to a certain extent.Therefore,it is of great significance to establish corresponding animal models based on ARC-related risk factors for in-depth study of the mechanism of ARC occurrence.This article reviews the related animal models from the diseases with high incidence of clinical ARC,aiming to provide reference for the development of ARC animal models.