Experimental study on anti-fatigue effect of Polysaccharides of Panax notoginseng
10.13699/j.cnki.1001-6821.2024.01.018
- VernacularTitle:三七多糖体内抗疲劳研究
- Author:
Pan-Pan WEI
1
;
Zi-Jun YAN
;
Meng-Yue DENG
;
Die XIA
;
Yu-Zhen DING
;
Lei ZHANG
;
Tong CHEN
Author Information
1. 昆明医科大学药学院暨云南省天然药物药理重点实验室,云南昆明 650500
- Keywords:
polysaccharides of Panax notoginseng;
exercise fatigue;
the loaded swimming;
the unloaded swimming;
anti-fatigue
- From:
The Chinese Journal of Clinical Pharmacology
2024;40(1):87-91
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of Polysaccharides of Panax notoginseng(PPN)on anti-exercise fatigue in mice.Methods One hundred male KM mice were randomly divided into negative control group,positive control group and experimental-L,-M,-H groups,with 20 cases per group.Experimental-L,-M,-H groups was given 100,200,400 mg·kg-1 PPN,respectively;positive control group was given 200 mg·kg-1 vitamin C;negative control group was given 0.1 mL·10 g-1 0.9％NaCl.Five groups were gavaged once a day for 28 days.After the last administration,the loaded swimming time was measured;after 90 minutes of the unloaded swimming test,the mice were allowed to rest for 30 minutes,the levels of lactic acid(LD),blood urea nitrogen(BUN),glycogen,and malondialdehyde(MDA)were measured,the safety of PPN with organ indices and histopathology.Results LD levels in negative control group,positive control group and experimental-L,-M,-Hgroupswere(4.76±0.84),(2.86±0.34),(3.00±0.69),(2.35±0.65)and(1.39±0.48)mg·kg-1;BUN contents were(13.65±1.25),(12.55±0.91),(12.12±1.24),(11.06±1.30)and(9.85±1.05)mmol·L-1;liver glycogen contents were(3.24±0.56),(11.11±2.16),(5.61±1.41),(6.60±1.49)and(12.05±2.25)mg·g-1;MDA levels were(2.36±0.21),(1.23±0.41),(1.93±0.23),(1.73±0.21)and(1.04±0.18)mg prot·mL-1.Compared with negative control group,the differences of above indexes in the positive control group and experimental-L,-M,-H groups were statistically significant(P＜0.05,P＜0.01,P＜0.001).Conclusion PPN can increase exercise endurance in mice and has an anti-fatigue effect.This study provides a theoretical basis for the application of PPN in the field of anti-fatigue research.
