Research status of dual-specificity phosphatase family and embryonic development
10.13699/j.cnki.1001-6821.2023.24.026
- VernacularTitle:双特异性磷酸酶家族与胚胎发育的研究现状
- Author:
Ran ZHANG
1
;
Jing-Suo WANG
;
Ya-Fen CHEN
;
Shen-Wei LI
;
Huai-Can ZHANG
;
Wei JI
;
Hai-Ying WANG
Author Information
1. 济宁医学院基础医学院,山东济宁 272067
- Keywords:
dual-specificity phosphatase(DUSP);
embryo development;
ear development;
dusp27;
muscle tissue
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(24):3664-3668
- CountryChina
- Language:Chinese
-
Abstract:
Embryo development is the main stage of the formation of various tissues,organs and systems.Abnormal embryo development can lead to embryo deformity and even death.Many factors are involved in this process.It was found that dual-specificity phosphatase(DUSP)could regulate the growth and development of different cells through a variety of signaling pathways,and it has been confirmed that the DUSPs family has an important association with embryonic development.A large amount of evidences showed that DUSPs and its downstream mitogen-activated protein kinase(MAPK)pathway played a key role in the regulation of gametogenesis,digestive system development and embryonic ear development.dusp27 is another extremely important gene whose role in early embryonic development remains to be studied,but it plays an important role in the development of embryonic muscle tissue.In this paper,the development of the above systems in DUSPs family was briefly reviewed in order to provide theoretical basis for the treatment of embryonic developmental diseases.
