Analysis of clinical cases of adverse reactions in children caused by pegaspargase
10.13699/j.cnki.1001-6821.2023.24.023
- VernacularTitle:培门冬酶致儿童不良反应临床病例分析
- Author:
Xiao-Lei REN
1
;
Yi-Qiu ZHAN
;
Chun-Yan ZHANG
;
Lin HUANG
;
Xiao-Hong ZHANG
Author Information
1. 北京大学人民医院药学部,北京 100044
- Keywords:
pegaspargase;
children;
adverse drug reactions;
medication safety
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(24):3653-3655
- CountryChina
- Language:Chinese
-
Abstract:
Objective Exploring the occurrence and clinical characteristics of adverse drug reactions caused by the treatment of malignant hematological diseases in children with pegaspargase,in order to provide reference for safe drug use in clinical practice.Methods Summarize and organize 24 cases of adverse reactions related to pegaspargase reported in the pediatric hematology ward of our hospital from January 2016 to June 2023 for analysis and re evaluation.The basic information,severity of adverse drug reaction(ADR),dosage,route of administration,clinical manifestations,occurrence time and outcome of ADR were analyzed statistically.Results Among the 24 ADR reports,there were 15 males(62.50％)and 9 females(37.50％).The age ranged from 2 to 15 years,with an average age of(7.79±4.68)years.There were 16 children under 10 years old(66.67％).The primary disease is acute lymphocytic leukemia(87.50％).The administration mode of 24 patients was intramuscular injection,and the dosage was 1200-3 750 U.A total of 30 AD Rs occurred in 24 patients,10 of which were serious ADRs.The most common organ involved in ADR was gastrointestinal system damage(8 cases,27.59％),followed by systemic(6 cases,20.69％)and skin and Subcutaneous tissue(5 cases,17.24％).The shortest occurrence time of ADR is 5 minutes after medication,and the longest is 56 days after medication.Conclusion Clinical attention should be paid to the occurrence characteristics of asparaginase ADR.After medication,patients need to be monitored for safety over a long period of time,closely monitoring their clinical symptoms and related test indicators,especially in young children,to reduce the damage caused by ADR to patients.
