Antimicrobial susceptibility of Gram-negative organisms:Results from China antimicrobial resistance surveillance trial(CARST)program,2021-2022
10.13699/j.cnki.1001-6821.2023.23.037
- VernacularTitle:中国细菌耐药监测研究(CARST)2021-2022年革兰氏阴性菌监测报告
- Author:
Yun LI
1
;
Bo ZHENG
;
Feng XUE
;
Xiu-Zhen ZHANG
;
Yun-Jian HU
;
Yu-Fen JIN
;
Jian-Hong ZHAO
;
Shi-Yang PAN
;
Wei GUO
;
Feng ZHAO
;
Yun-Song YU
;
Xuan CAI
;
Wen-En LIU
;
De-Hua LIU
;
Ying FEI
;
Jia-Yun LIU
;
Feng-Yan PEI
;
Ling MENG
;
Ping JI
;
Jin TANG
;
Kai XU
;
Lei ZHU
;
Cun-Wei CAO
;
He-Ping XU
;
Shan WANG
;
Lan-Qing CUI
;
Jia ZHANG
;
Yao-Yao LIU
Author Information
1. 北京大学第一医院临床药理研究所,北京 100034
- Keywords:
antimicrobial resistance surveillance;
Gram-negative bacteria;
minimum inhibitory concentration;
susceptibility;
resistance;
minimal inhibitory concentration distribution
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(23):3525-3544
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the Gram-negative bacteria resistance in nationwide's tertiary hospitals and understand the trend of antimicrobial resistance.Method All the clinical isolates were collected from 19 hospitals and the minimal inhibitory concentrations(MICs)were tested using agar/broth dilution method recommended.Results A total of 4 066 pathogenic isolates from 19 tertiary hospitals in 19 cities nationwide over the period from July 2021 to June 2022 were studied.Based on the MIC results,Escherichia coli and Klebsiella pneumoniae showed extended spectrum β-lactamase(ESBLs)phenotype rates of 55.0％and 21.0％,respectively,ESBLs phenotype rate of Klebsiella pneumoniae keep going down.The ratios of carbapenems resistance Klebsiella pneumoniae increased by 5 percentage points compared with the previous monitoring.Carbapenems,moxalactam,sitafloxacin,β-lactam combination agents,fosfomycin trometamol,and amikacin displayed desirable antibacterial activity against Enterbacterales,susceptibal rates were above 75％.In addition,tigacycline,omacycline,colistin and fluoxefin maintained good antibacterial activity against their respective effective bacteria/species,and the bacterial sensitivity rates by more than 80％.Resistance rates of Pseudomonas aeruginosa and Acinetobacter baumannnii to imipenem were 26.3％and 72.1％and multidrug-resistant(MDR)detection rates were 41.1％and 77.3％,extensively drug-resistant(XDR)were 12.0％and 71.8％,respectively.Comparison of drug resistance rates from different wards,ages and specimen sources indicated that the proportion of resistance in Klebsiella pneumoniae and Acinetobacter baumannii isolated from intensive care unit(ICU)were significantly higher than non-ICU.Carbapenem resistance rates of Klebsiella pneumoniae isolated from ICU were more than 35％.Resistance rates of Haemophilus influenzae isolated in children to β-lactam,macrolide,clindamycin and ESBLs detection rate in Klebsiella pneumoniae isolated from children were more than those from adults and the old people,so bacterial resistance in children is an important problem in China.Conclusion ESBLs detection rate of Escherichia coli increased slightly after years of continuous decline.The proportion of carbapenem resistant Pseudomonas aeruginosa was stable,but the resistance rate of Klebsiella pneumoniae and Acinetobacter baumannii to carbapenems was still increased,which should be paid more attention.
