Antimicrobial susceptibility of Gram-positive organisms:Results from China antimicrobial resistance surveillance trial(CARST)program,2021-2022
10.13699/j.cnki.1001-6821.2023.23.036
- VernacularTitle:中国细菌耐药监测研究(CARST)2021-2022年革兰氏阳性菌监测报告
- Author:
Yun LI
1
;
Bo ZHENG
;
Feng XUE
;
Xiu-Zhen ZHANG
;
Yun-Jian HU
;
Yu-Fen JIN
;
Jian-Hong ZHAO
;
Shi-Yang PAN
;
Wei GUO
;
Feng ZHAO
;
Yun-Song YU
;
Xuan CAI
;
Wen-En LIU
;
De-Hua LIU
;
Ying FEI
;
Jia-Yun LIU
;
Feng-Yan PEI
;
Ling MENG
;
Ping JI
;
Jin TANG
;
Kai XU
;
Lei ZHU
;
Cun-Wei CAO
;
He-Ping XU
;
Shan WANG
;
Lan-Qing CUI
;
Jia ZHANG
;
Yao-Yao LIU
Author Information
1. 北京大学第一医院临床药理研究所,北京 100034
- Keywords:
antimicrobial resistance surveillance;
Gram-positive cocci;
minimum inhibitory concentration;
susceptibility;
resistance;
minimal inhibitory concentration distribution
- From:
The Chinese Journal of Clinical Pharmacology
2023;39(23):3509-3524
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the Gram-positive coccus resistance in nationwide's tertiary hospitals and understand the trend of antimicrobial resistance.Methods All the clinical isolates were collected from 19 hospitals and the minimal inhibitory concentrations(MICs)were tested using agar/broth dilution method recommended.Results A total of 1 974 pathogenic Gram-positive coccus from 19 tertiary hospitals in 19 cities nationwide over the period from July 2021 to June 2022 were studied.Based on the MIC results,the prevalence of methicillin resistant Stapylococcus aureus(MRSA)and methicillin resistant Stapylococcus epidermidis(MRSE)were 36.4％and 79.9％respectively.No vancomycin insensitivity Staphylococcus was detected.Staphylococcus aureus were 100％susceptibility to linezolid and teicoplanin.Antibiotic resistance rate of Enterococcus faecalis and Enterococcus faecium to ampicillin were 3.1％and 92.9％.The detectation rate of vancomycin resistant Enterococcus(VRE)was 1.6％.Nonsusceptibility rate of Enterococcus faecalis to linezolid was 32.2％,two consecutive monitoring rises and nonsusceptibility rate of Enterococcus faecium(12.5％)was also significantly increased.The prevalence of penicillin non-susceptible Streptococcus pneumoniae(PNSSP)was 0.8％based on non-meningitis and parenteral administration criterion,decrease of nearly 30 percentage points from the previous surveillance.While for cases of oral penicillin,the rate was 71.8％,showing similar to last time.The results indicated that the number of strains with higher MIC value of penicillin(MIC ≥4 mg·L-1)decreased significantly.There were no significant differences of resistance rates of Stapylococcus aureus,Stapylococcus epidermidis,Enterococcus faecalis,Enterococcus faecium and Streptococcus pneumoniae among various groups such as different department,age,or specimen source.Conclusion VRE detection ratio stablized at a relatively low level.The number of Streptococcus pneumoniae with higher MIC value of penicillin decreased significantly compared with the previous monitoring.The increase of linezolidin-insensitive Enterococcus was noteworthy.
